The disease, because of inherited only by X chromosomes, is mainly faced at males. Males have only one X chromosome, so carrying disease is out of the question. The male children of patient fathers have no risk of both disease and carrying the disease. But all the female children are disease carrier. Because of the fact that females have a pair of X chromosome, The disease cannot be seen only by mutant gene, so females are disease carrier. The risk for the male children of disease carrier mothers is 50% for the disease, for female children is 50% for being a disease carrier.

Because of dose compensation at women one of X chromosomes is randomized and becomes inactive. The expectation from a normal woman who has a mutant gene is at half of the cells the chromosome carrying normal gene and at the other half of the cells the chromosome carrying the mutant gene to be inactivated. However sometimes X chromosome carrying the normal gene can be inactivated, and therefore the disease show itself phenotypically.

And sometimes at X autosomal translocations, to be able save genetic structure, translocated X is saved and the other X chromosome is inactivated.