Molecular Genetics

• Breast Cancer - BRCA1 & BRCA2
• Familial Non-Poliposis Colon Cancer
• Colorectal Cancer - APC
• Bladder and Cervix Cancer - FGFR3
• Lung Cancer - EGFR
• c-KIT
• PDGFRA
• PDGFRB
• P53
• Ret
• K-ras
• Jak-2
• FLT3
• 5-Fluorourasil toxicity
• Chimerism analysis
• Bcr-Abl - t(9;22)
• Pml-Rara - t(15,17)
• Microsatellit Instability (MSI)
• NPM1
• CEBPA

Molecular Cytogenetics (FISH)

• Her2/Neu (c-erbB2) (17q11-12)
• 1p/19q deletion
• EGFR (7p11.1-q11.1)
• TOP2A
• FIP1L1/PDGFRA
• EML4-ALK
• IGF1R
• P53 (17p13.1)
• Myc (8q24)
• MLL (11q24)
• EGR1 (5/5q-)
• D7S486 (7/7q-)
• D13S319 (del13q14.3)
• RB1 (13q14)
• LAMP1 (13q34)
• MALT1 (18q21)
• 13q14.3 (D13S319) /13q34 (LAMP1)/CEP12
• CEP 8
• CEP 12
• t(9;22) - BCR/ABL
• t(15;17) - PML/RARA
• t( 8;21) - AML 1/ETO
• t(8;14) - IGH/MYC
• t(11;14) - IGH/CCND1
• t(14;18) - IGH/BCL2
• (4;14) - IGH/FGFR3
• t(12;21) - TEL/AML1
• t(16;16), inv(16) - CBFB
• t(17p11.2-q21) - SMS/RARA
• ATM/P53 (11q23-17p13.1)
• Chimerisim following (X and Y)

Cytogenetics

• Chromosome analysis from bone marrow
• Chromosome analysis from peripheral blood